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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2504
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dio1
Name: iodothyronine deiodinase 1
Acc ID: CHEBI:5516
Term: sodium aurothiomalate
Definition: A variable mixture of the mono- and di-sodium salts of aurothiomalic acid. It is used for treatment of rheumatoid arthritis.
Chemical ID: MESH:D006052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dio1decreases activityISODIO1 (Homo sapiens)6480464CTDGold Sodium Thiomalate results in decreased activity of DIO1 proteinPMID:34662569
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