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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dhfr
Name: dihydrofolate reductase
Acc ID: CHEBI:38757
Term: isoflavones
Definition: Any isoflavonoid with a 3-aryl-1-benzopyran-4-one (3-aryl-4H-chromen-4-one) skeleton and its substituted derivatives.
Chemical ID: MESH:D007529
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dhfrdecreases expressionISODHFR (Homo sapiens)6480464CTDIsoflavones results in decreased expression of DHFR mRNAPMID:17374662
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