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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2483
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp7b1
Name: cytochrome P450 family 7 subfamily B member 1
Acc ID: CHEBI:75170
Term: zaragozic acid A
Definition: A polyketide isolated from fungi that is a potent inhibitor of fungal and mammalian squalene synthase.
Chemical ID: MESH:C075117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp7b1decreases activityEXP 6480464CTDsqualestatin 1 results in decreased activity of CYP7B1 proteinPMID:12029625
Cyp7b1decreases expressionEXP 6480464CTDsqualestatin 1 results in decreased expression of CYP7B1 mRNAPMID:12029625
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