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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1decreases activityEXP 6480464CTDCisplatin results in decreased activity of CYP2E1 proteinPMID:24882083
Cyp2e1increases expressionEXP 6480464CTDCisplatin results in increased expression of CYP2E1 mRNAPMID:22023808
Cyp2e1increases response to substanceEXP 6480464CTDCYP2E1 protein results in increased susceptibility to CisplatinPMID:20809784
Cyp2e1multiple interactionsEXP 6480464CTDturmeric extract affects the reaction [Cisplatin results in decreased activity of CYP2E1 protein]PMID:24882083
Cyp2e1increases expressionISOCyp2e1 (Mus musculus)6480464CTDCisplatin results in increased expression of CYP2E1 proteinPMID:23770416 PMID:25043994
Cyp2e1multiple interactionsISOCyp2e1 (Mus musculus)6480464CTDChlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of CYP2E1 protein]; Cisplatin results in increased expression of and results in increased activity of CYP2E1 protein; Luteolin inhibits the reaction [Cisplatin results in increased expression of CYP2E1 protein]PMID:21616140 PMID:23770416 PMID:25043994
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