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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:254496
Term: 7,12-dimethyltetraphene
Definition: A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.
Chemical ID: MESH:D015127
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1increases expressionEXP 6480464CTD9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP2E1 mRNAPMID:24576726
Cyp2e1affects response to substanceISOCyp2e1 (Mus musculus)6480464CTDCYP2E1 protein affects the susceptibility to 9,10-Dimethyl-1,2-benzanthracenePMID:18622027
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