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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2460
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:45716
Term: vorinostat
Definition: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Chemical ID: MESH:C111237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1b1decreases expressionISOCYP1B1 (Homo sapiens)6480464CTDvorinostat results in decreased expression of CYP1B1 mRNAPMID:18769122
Cyp1b1increases expressionISOCYP1B1 (Homo sapiens)6480464CTDvorinostat results in increased expression of CYP1B1 mRNAPMID:26272509
Cyp1b1multiple interactionsISOCYP1B1 (Homo sapiens)6480464CTD[NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYP1B1 mRNA; Vorinostat inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]PMID:15713371 PMID:27188386
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