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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2456
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:47519
Term: ketoconazole
Definition: A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole.
Chemical ID: MESH:D007654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp17a1decreases activityEXP 6480464CTDKetoconazole results in decreased activity of CYP17A1 proteinPMID:15934942 PMID:25993309
Cyp17a1decreases expressionEXP 6480464CTDKetoconazole results in decreased expression of CYP17A1 mRNAPMID:36653537
Cyp17a1decreases activityISOCYP17A1 (Homo sapiens)6480464CTDKetoconazole results in decreased activity of CYP17A1 proteinPMID:11118046 PMID:15743198 PMID:15771425 PMID:31330226 PMID:31982514 PMID:38795739
Cyp17a1decreases expressionISOCYP17A1 (Homo sapiens)6480464CTDKetoconazole results in decreased expression of CYP17A1 mRNAPMID:16935330
Cyp17a1multiple interactionsISOCYP17A1 (Homo sapiens)6480464CTDKetoconazole inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]PMID:16935330
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