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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2383
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cort
Name: cortistatin
Acc ID: CHEBI:7071
Term: N,N-diethyl-m-toluamide
Definition: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of m-toluic acid with the nitrogen of diethylamine. First developed by the U.S. Army in 1946 for use by military personnel in insect-infested areas, it is the most widely used insect repellent worldwide.
Chemical ID: MESH:D003671
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cortmultiple interactionsISOCort (Mus musculus)6480464CTD[CORT protein co-treated with Pyridostigmine Bromide co-treated with DEET co-treated with Isoflurophate] affects the secretion of IL10 protein; [CORT protein co-treated with Pyridostigmine Bromide co-treated with DEET] affects the secretion of IL10 protein; [Pyridostigmine Bromide co-treated with DEET] affects the reaction [[CORT protein co-treated with Isoflurophate] affects the secretion of IL5 protein]; [Pyridostigmine Bromide co-treated with DEET] inhibits the reaction [[CORT protein co-treated with Isoflurophate] results in increased expression of LIF mRNA]; [Pyridostigmine Bromide co-treated with DEET] promotes the reaction [CORT protein inhibits the reaction [Isoflurophate results in increased expression of IL1B mRNA]]; [Pyridostigmine Bromide co-treated with DEET] promotes the reaction [CORT protein inhibits the reaction [Isoflurophate results in increased expression of IL6 mRNA]]; [Pyridostigmine Bromide co-treated with DEET] promotes the reaction [CORT protein inhibits the reaction [Isoflurophate results in increased expression of OSM mRNA]]PMID:30339781
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