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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2375
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col2a1
Name: collagen type II alpha 1 chain
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col2a1multiple interactionsEXP 6480464CTDCadmium Chloride affects the reaction [COL2A1 protein results in decreased expression of CAT protein]; Cadmium Chloride affects the reaction [COL2A1 protein results in increased expression of IL6 protein]; Cadmium Chloride affects the reaction [COL2A1 protein results in increased expression of PTGS2 protein]; Cadmium Chloride affects the reaction [COL2A1 protein results in increased expression of RELA protein]; Cadmium Chloride affects the reaction [COL2A1 protein results in increased expression of TNF protein]; Cadmium Chloride affects the reaction [COL2A1 protein results in increased secretion of ELANE protein]PMID:26070417
Col2a1decreases expressionISOCOL2A1 (Homo sapiens)6480464CTDCadmium Chloride results in decreased expression of COL2A1 mRNAPMID:38382870
Col2a1multiple interactionsISOCol2a1 (Mus musculus)6480464CTD[Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of COL2A1 mRNAPMID:31904401
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