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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2348
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrna7
Name: cholinergic receptor nicotinic alpha 7 subunit
Acc ID: CHEBI:39178
Term: clothianidin
Definition: An N-nitro compound consisting of 2-nitroguanidine having a (2-chloro-1,3-thiazol-5-yl)methyl group at position 1 and a methyl group at position 3.
Chemical ID: MESH:C480342
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrna7decreases expressionISOChrna7 (Mus musculus)6480464CTDclothianidin results in decreased expression of CHRNA7 mRNAPMID:35264496
Chrna7increases activityISOCHRNA7 (Homo sapiens)6480464CTDclothianidin results in increased activity of CHRNA7 protein; clothianidin results in increased activity of CHRNA7 protein mutant formPMID:39393466
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