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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2332
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cftr
Name: CF transmembrane conductance regulator
Acc ID: CHEBI:31401
Term: cilostazol
Definition: A lactam that is 3,4-dihydroquinolin-2(1H)-one in which the hydrogen at position 6 is substituted by a 4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy group.
Chemical ID: MESH:C045645
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cftrincreases activityISOCFTR (Homo sapiens)6480464CTDcilostazol results in increased activity of CFTR proteinPMID:12714375
Cftrmultiple interactionsISOCFTR (Homo sapiens)6480464CTDcilostazol promotes the reaction [CFTR protein affects the secretion of Chlorides]PMID:12714375
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