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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2319357
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfatc1
Name: nuclear factor of activated T-cells 1
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfatc1decreases activityISONfatc1 (Mus musculus)6480464CTDHydrogen Peroxide results in decreased activity of NFATC1 proteinPMID:12203019
Nfatc1multiple interactionsISONfatc1 (Mus musculus)6480464CTD[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA; [Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 protein]; Hydrogen Peroxide inhibits the reaction [Ionomycin results in decreased phosphorylation of NFATC1 protein]PMID:12203019 PMID:33754447
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