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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2299
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cd28
Name: Cd28 molecule
Acc ID: CHEBI:50692
Term: mifepristone
Definition: A 3-oxo steroid that has formula 429.59374.
Chemical ID: MESH:D015735
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cd28multiple interactionsISOCD28 (Homo sapiens)6480464CTDMifepristone inhibits the reaction [[Dexamethasone co-treated with CD28 protein] results in increased expression of NFKBIA mRNA]; Mifepristone inhibits the reaction [[rimexolone co-treated with CD28 protein] results in increased expression of NFKBIA mRNA]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [CD28 protein results in increased secretion of IFNG protein]]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [CD28 protein results in increased secretion of IL2 protein]]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [CD28 protein results in increased secretion of TNF protein]]; Mifepristone inhibits the reaction [rimexolone inhibits the reaction [CD28 protein results in increased secretion of IFNG protein]]; Mifepristone inhibits the reaction [rimexolone inhibits the reaction [CD28 protein results in increased secretion of IL2 protein]]; Mifepristone inhibits the reaction [rimexolone inhibits the reaction [CD28 protein results in increased secretion of TNF protein]]PMID:20363256
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