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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2282
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Runx2
Name: RUNX family transcription factor 2
Acc ID: CHEBI:16796
Term: melatonin
Definition: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.
Chemical ID: MESH:D008550
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Runx2multiple interactionsEXP 6480464CTDMelatonin inhibits the reaction [Cadmium Chloride results in decreased expression of RUNX2 mRNA]PMID:31809235
Runx2increases expressionISORUNX2 (Homo sapiens)6480464CTDMelatonin results in increased expression of RUNX2 mRNAPMID:20738756
Runx2multiple interactionsISORUNX2 (Homo sapiens)6480464CTDMelatonin inhibits the reaction [Glucose results in decreased expression of RUNX2 mRNA]; Melatonin inhibits the reaction [Glucose results in decreased expression of RUNX2 protein]PMID:38000455
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