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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:64163
Term: diquat
Definition: The organic cation formed formally by addition of an ethylene bridge between the nitrogen atoms of 2,2'-bipyridine. Most often available as the dibromide.
Chemical ID: MESH:D004178
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catincreases activityEXP 6480464CTDDiquat results in increased activity of CAT proteinPMID:37277018
Catdecreases activityISOCat (Mus musculus)6480464CTDDiquat results in decreased activity of CAT proteinPMID:26785375 PMID:27057282 PMID:36572071
Catdecreases expressionISOCat (Mus musculus)6480464CTDDiquat results in decreased expression of CAT mRNAPMID:36572071
Catmultiple interactionsISOCAT (Homo sapiens)6480464CTDCAT protein inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]PMID:21215309
Catmultiple interactionsISOCat (Mus musculus)6480464CTD3,4-dihydroxyphenylethanol inhibits the reaction [Diquat results in decreased activity of CAT protein]; 3,4-dihydroxyphenylethanol inhibits the reaction [Diquat results in decreased expression of CAT mRNA]; CAT protein inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; procyanidin B2 inhibits the reaction [Diquat results in decreased activity of CAT protein]PMID:21215309 PMID:27057282 PMID:36572071
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