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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:63918
Term: artesunate
Definition: An artemisinin derivative that is the hemisuccinate ester of the lactol resulting from the reduction of the lactone carbonyl group of artemisinin. It is used, generally as the sodium salt, for the treatment of malaria.
Chemical ID: MESH:C039726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catdecreases response to substanceISOCAT (Homo sapiens)6480464CTDCAT protein results in decreased susceptibility to artesunatePMID:20144594
Catincreases expressionISOCAT (Homo sapiens)6480464CTDartesunate results in increased expression of CAT proteinPMID:19513562 PMID:20144594
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