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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:34910
Term: pentetrazol
Definition: An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Chemical ID: MESH:D010433
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases expressionEXP 6480464CTDPentylenetetrazole results in increased expression of CASP3 mRNA; Pentylenetetrazole results in increased expression of CASP3 proteinPMID:33771525 PMID:34266355
Casp3multiple interactionsEXP 6480464CTDThiamine inhibits the reaction [Pentylenetetrazole results in increased expression of CASP3 protein]; Topiramate inhibits the reaction [Pentylenetetrazole results in increased expression of CASP3 mRNA]PMID:33771525 PMID:34266355
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