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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2264
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Camk4
Name: calcium/calmodulin-dependent protein kinase IV
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Camk4increases activityISOCAMK4 (Homo sapiens)6480464CTDEstradiol results in increased activity of CAMK4 proteinPMID:16413991
Camk4multiple interactionsISOCAMK4 (Homo sapiens)6480464CTD2',3',4',5'-tetrachloro-4-biphenylol inhibits the reaction [Estradiol results in increased activity of CAMK4 protein]; [Estradiol co-treated with TGFB1 protein] results in increased expression of CAMK4 mRNAPMID:16413991 PMID:30165855
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