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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2218
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Brca1
Name: BRCA1, DNA repair associated
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Brca1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of BRCA1 mRNAPMID:25181051
Brca1increases expressionEXP 6480464CTDbisphenol A results in increased expression of BRCA1 mRNAPMID:27208089 PMID:32145629
Brca1affects response to substanceISOBRCA1 (Homo sapiens)6480464CTDBRCA1 protein affects the susceptibility to bisphenol APMID:20868731
Brca1decreases expressionISOBRCA1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of BRCA1 mRNAPMID:16029874
Brca1increases expressionISOBRCA1 (Homo sapiens)6480464CTDbisphenol A results in increased expression of BRCA1 mRNA; bisphenol A results in increased expression of BRCA1 proteinPMID:22576693 PMID:25933419
Brca1increases methylationISOBrca1 (Mus musculus)6480464CTDbisphenol A results in increased methylation of BRCA1 promoterPMID:27312807
Brca1increases methylationISOBRCA1 (Homo sapiens)6480464CTDbisphenol A results in increased methylation of BRCA1 genePMID:22258036
Brca1increases response to substanceISOBrca1 (Mus musculus)6480464CTDBRCA1 gene mutant form results in increased susceptibility to bisphenol APMID:20868731
Brca1multiple interactionsISOBRCA1 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in increased methylation of BRCA1 gene; [naringenin co-treated with bisphenol A] results in increased expression of BRCA1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BRCA1 mRNA; BRCA1 protein affects the reaction [bisphenol A results in increased activity of ESR1 protein]; MYC protein promotes the reaction [bisphenol A results in increased expression of BRCA1 protein]PMID:20868731 PMID:25933419 PMID:31601247 PMID:36235125
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