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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2213
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bmp4
Name: bone morphogenetic protein 4
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bmp4decreases expressionEXP 6480464CTDDibutyl Phthalate results in decreased expression of BMP4 mRNA; Dibutyl Phthalate results in decreased expression of BMP4 proteinPMID:19464577 PMID:22027561 PMID:25213187 PMID:26948521 PMID:27079746 PMID:28341571
Bmp4increases expressionEXP 6480464CTDDibutyl Phthalate results in increased expression of BMP4 mRNAPMID:15829613
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