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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2202
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bdnf
Name: brain-derived neurotrophic factor
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bdnfincreases expressionEXP 6480464CTDCyclophosphamide results in increased expression of BDNF mRNA; Cyclophosphamide results in increased expression of BDNF proteinPMID:10683293 PMID:32615180
Bdnfmultiple interactionsEXP 6480464CTDO-1602 compound inhibits the reaction [Cyclophosphamide results in increased expression of BDNF protein]PMID:32615180
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