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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2198
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bckdk
Name: branched chain ketoacid dehydrogenase kinase
Acc ID: CHEBI:9516
Term: thapsigargin
Definition: An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.
Chemical ID: MESH:D019284
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bckdkdecreases expressionISOBCKDK (Homo sapiens)6480464CTDThapsigargin results in decreased expression of BCKDK mRNAPMID:22378314
Bckdkdecreases expressionISOBckdk (Mus musculus)6480464CTDThapsigargin results in decreased expression of BCKDK proteinPMID:24648495
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