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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2165
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atf3
Name: activating transcription factor 3
Acc ID: CHEBI:139047
Term: GSK2656157
Definition: A pyrrolopyrimidine that is 7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine which has been substituted at position 5 by a 4-fluoro-2,3-dihydro-1H-indol-5-yl group, the nitrogen of which has been acylated by a (6-methylpyridin-2-yl)acetyl group. An orally bioavailable PERK inhibitor.
Chemical ID: MESH:C000597302
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atf3multiple interactionsISOAtf3 (Mus musculus)6480464CTDGSK2656157 inhibits the reaction [pegaspargase promotes the reaction [ATF3 protein binds to FGF21 promoter]]PMID:38582373
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