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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2123
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Apc
Name: APC regulator of WNT signaling pathway
Acc ID: CHEBI:48843
Term: disodium selenite
Definition: An inorganic sodium salt composed of sodium and selenite ions in a 2:1 ratio.
Chemical ID: MESH:D018038
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Apcdecreases methylationISOAPC (Homo sapiens)6480464CTDSodium Selenite results in decreased methylation of APC promoterPMID:18676679
Apcincreases expressionISOAPC (Homo sapiens)6480464CTDSodium Selenite results in increased expression of APC mRNAPMID:18676679
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