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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:52288
Term: 1-octadec-9-enoylglycero-3-phosphate
Definition: A 2-lysophosphatidic acid that has formula C21H41O7P.
Chemical ID: MESH:C032881
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1increases phosphorylationEXP 6480464CTDlysophosphatidic acid results in increased phosphorylation of AKT1 proteinPMID:14769825
Akt1multiple interactionsEXP 6480464CTD1-Butanol inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of AKT1 protein]; exoenzyme C3, Clostridium botulinum inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of AKT1 protein]PMID:14769825
Akt1increases phosphorylationISOAKT1 (Homo sapiens)6480464CTDlysophosphatidic acid results in increased phosphorylation of AKT1 proteinPMID:17550345 PMID:20103642
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTD2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of AKT1 protein]PMID:17550345 PMID:20103642
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