GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Parp1 | decreases response to substance | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | PARP1 protein results in decreased susceptibility to Mitomycin | PMID:28757444 | Parp1 | increases activity | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Mitomycin results in increased activity of PARP1 protein | PMID:15905168 | Parp1 | increases cleavage | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Mitomycin results in increased cleavage of PARP1 protein | PMID:24124520 | Parp1 | multiple interactions | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | CDKN1A mutant form inhibits the reaction [Chloramphenicol inhibits the reaction [Mitomycin results in increased activity of PARP1 protein]]; Chloramphenicol inhibits the reaction [Mitomycin results in increased activity of PARP1 protein]; Mitomycin promotes the reaction [Ouabain results in increased cleavage of PARP1 protein]; Ouabain promotes the reaction [Mitomycin results in increased cleavage of PARP1 protein] | PMID:15905168 PMID:24124520 | | ||||||||||||||||||||||
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