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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:17515
Term: L-gamma-glutamyl-L-cysteine
Definition: A molecular entity formed when L-cysteine amino group binds to the gamma-carbonyl of L-glutamic acid.
Chemical ID: MESH:C017341
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1multiple interactionsEXP 6480464CTDAKT activator SC79 inhibits the reaction [gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of PARP1 protein]]; Anisomycin inhibits the reaction [gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of PARP1 protein]]; gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of PARP1 protein]PMID:34767868
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