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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2038
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adcyap1r1
Name: ADCYAP receptor type I
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adcyap1r1affects methylationISOADCYAP1R1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of ADCYAP1R1 5' UTR; Benzo(a)pyrene affects the methylation of ADCYAP1R1 promoterPMID:27901495
Adcyap1r1increases expressionISOAdcyap1r1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of ADCYAP1R1 mRNAPMID:22228805
Adcyap1r1increases mutagenesisISOADCYAP1R1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased mutagenesis of ADCYAP1R1 genePMID:25435355
Adcyap1r1multiple interactionsISOAdcyap1r1 (Mus musculus)6480464CTDAHR protein affects the reaction [Benzo(a)pyrene affects the expression of ADCYAP1R1 mRNA]PMID:22228805
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