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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2023
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acp3
Name: acid phosphatase 3
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acp3decreases expressionEXP 6480464CTDEstradiol results in decreased expression of ACP3 mRNAPMID:32145629
Acp3decreases expressionISOACP3 (Homo sapiens)6480464CTDEstradiol results in decreased expression of ACP3 mRNAPMID:12391264 PMID:23019147 PMID:31614463
Acp3increases expressionISOACP3 (Homo sapiens)6480464CTDEstradiol results in increased expression of ACP3 mRNAPMID:21795739
Acp3multiple interactionsISOACP3 (Homo sapiens)6480464CTD[Estradiol co-treated with Norethindrone Acetate] results in increased expression of ACP3 mRNA; [Estradiol co-treated with TGFB1 protein] results in decreased expression of ACP3 mRNA; [Progesterone co-treated with Estradiol] results in decreased expression of ACP3 mRNA; Progesterone inhibits the reaction [Estradiol results in increased expression of ACP3 mRNA]PMID:17404688 PMID:21795739 PMID:22217510 PMID:30165855
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