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GENE - TERM ANNOTATION REPORT

RGD ID: 18918561
Species: Heterocephalus glaber
RGD Object: Gene
Symbol: Eif3k
Name: eukaryotic translation initiation factor 3 subunit K
Acc ID: GO:0005852
Term: eukaryotic translation initiation factor 3 complex
Definition: A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs.
Definition Source(s): PMID:15904532
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif3kpart_ofIEAUniProtKB:Q9DBZ5 or UniProtKB:Q9UBQ5 or ensembl:ENSMUSP00000066038 or ensembl:ENSP00000248342150520179Ensembl GO_REF:0000107
Eif3kpart_ofIEAInterPro:IPR009374 or InterPro:IPR016020150520179InterPro GO_REF:0000002
Eif3kpart_ofIEAPANTHER:PTN000314732150520179TreeGrafter GO_REF:0000118
Eif3kpart_ofIEAUniRule:UR000107107150520179UniProt GO_REF:0000104
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