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GENE - TERM ANNOTATION REPORT

RGD ID: 18450230
Species: Chlorocebus sabaeus
RGD Object: Gene
Symbol: CHRNA5
Name: cholinergic receptor nicotinic alpha 5 subunit
Acc ID: DOID:0081013
Term: severe COVID-19
Definition: A COVID-19 that is characterized by any of (1) Oxygen saturation < 90% on room air, (2) Respiratory rate > 30 breaths/min in adults and children > 5 years old, ≥ 60 breaths/min in children < 2 months old, ≥ 50 in children 2–11 months old, and ≥ 40 in children 1–5 years old, or (3) signs of severe respiratory distress (accessory muscle use, inability to complete full sentences, and, in children, very severe chest wall indrawing, grunting, central cyanosis, or presence of any other general danger signs. (DO)
Definition Source(s): https://www.who.int/publications/i/item/WHO-2019-nCoV-clinical-2021-1 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CHRNA5 ISOCHRNA5 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Susceptibility to severe coronavirus disease (COVID-19) due to high levels of fibrinogen and C-reactive proteinPMID:18385738 PMID:18385739 PMID:18618000 PMID:19132693 PMID:19443489 PMID:19706762 PMID:20485328 PMID:20643934 PMID:20840187 PMID:20886544 PMID:21418140 PMID:22046326 PMID:22648373 PMID:22992668 PMID:24733007 PMID:27355804 PMID:29196725 PMID:29621993 PMID:29666375 PMID:30453884 PMID:31402126 PMID:31796940
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