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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1642413
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2c69
Name: cytochrome P450, family 2, subfamily c, polypeptide 69
Acc ID: CHEBI:27999
Term: tolbutamide
Definition: An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
Chemical ID: MESH:D014044
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c69increases metabolic processingEXP 6480464CTDCYP2C69 protein results in increased metabolism of TolbutamidePMID:30503582
Cyp2c69multiple interactionsEXP 6480464CTD[CYP2C69 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamidePMID:30503582
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