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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1621892
Species: Mus musculus
RGD Object: Gene
Symbol: Spink14
Name: serine peptidase inhibitor, Kazal type 14
Acc ID: CHEBI:40036
Term: amitrole
Definition: A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.
Chemical ID: MESH:D000640
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Spink14decreases expressionISOSpink14 (Rattus norvegicus)6480464CTDAmitrole results in decreased expression of SPINK14 mRNAPMID:30047161
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