Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	1621562
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Tslp
Name:	thymic stromal lymphopoietin

Acc ID:	CHEBI:37537
Term:	phorbol 13-acetate 12-myristate
Definition:	A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID:	MESH:D013755

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Tslp	multiple interactions	EXP		38549374	RGD	Phorbol 12-myristate 13-acetate increases expression of Tslp protein in keratinocytes
Tslp	increases expression	EXP		6480464	CTD	Tetradecanoylphorbol Acetate results in increased expression of TSLP mRNA; Tetradecanoylphorbol Acetate results in increased expression of TSLP protein	PMID:29462589 PMID:35717073
Tslp	increases secretion	EXP		6480464	CTD	Tetradecanoylphorbol Acetate results in increased secretion of TSLP protein	PMID:29462589
Tslp	multiple interactions	EXP		6480464	CTD	FK3453 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TSLP protein]; lithol rubine BCA analog promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of TSLP mRNA]; lithol rubine BCA analog promotes the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TSLP protein]; lithol rubine BCA promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of TSLP mRNA]; lithol rubine BCA promotes the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TSLP protein]	PMID:29462589 PMID:35717073
Tslp	increases expression	ISO	TSLP (Homo sapiens)	6480464	CTD	Tetradecanoylphorbol Acetate results in increased expression of TSLP mRNA	PMID:18049884
Tslp	increases secretion	ISO	TSLP (Homo sapiens)	6480464	CTD	Tetradecanoylphorbol Acetate results in increased secretion of TSLP protein	PMID:18049884
Tslp	multiple interactions	ISO	TSLP (Homo sapiens)	6480464	CTD	[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TSLP mRNA; [Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TSLP protein; Dexamethasone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TSLP protein]; FK3453 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TSLP mRNA]; naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TSLP mRNA]; naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TSLP protein]; Plant Preparations inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TSLP mRNA]; Plant Preparations inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TSLP protein]	PMID:24131540 PMID:35717073

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