TSLP (thymic stromal lymphopoietin) - Rat Genome Database

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Gene: TSLP (thymic stromal lymphopoietin) Homo sapiens
Analyze
Symbol: TSLP
Name: thymic stromal lymphopoietin
RGD ID: 1604556
HGNC Page HGNC:30743
Description: Enables cytokine activity and interleukin-7 receptor binding activity. Involved in several processes, including defense response to other organism; positive regulation of cytokine production; and positive regulation of signal transduction. Located in extracellular region. Is active in extracellular space. Biomarker of common cold and respiratory syncytial virus infectious disease.
Type: protein-coding
RefSeq Status: REVIEWED
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385111,070,062 - 111,078,026 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5111,070,062 - 111,078,026 (+)EnsemblGRCh38hg38GRCh38
GRCh375110,405,760 - 110,413,724 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365110,435,289 - 110,441,623 (+)NCBINCBI36Build 36hg18NCBI36
Celera5106,353,329 - 106,359,661 (+)NCBICelera
Cytogenetic Map5q22.1NCBI
HuRef5105,584,896 - 105,592,841 (+)NCBIHuRef
CHM1_15109,839,103 - 109,847,047 (+)NCBICHM1_1
T2T-CHM13v2.05111,580,695 - 111,588,660 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->3)-beta-D-glucan  (EXP)
1,2-dichloroethane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (EXP)
2-palmitoylglycerol  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
aluminium hydroxide  (ISO)
amiodarone  (EXP)
amorolfine  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
benomyl  (EXP)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
beta-eudesmol  (ISO)
bisphenol A  (EXP,ISO)
butenafine  (EXP)
Calcimycin  (EXP)
calcipotriol  (ISO)
calcitriol  (EXP,ISO)
ceric oxide  (EXP)
CGP 52608  (EXP)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cordycepin  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (EXP)
DDE  (EXP)
deguelin  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (ISO)
Didecyldimethylammonium  (ISO)
diethyl malate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
ethylparaben  (EXP)
ferric oxide  (ISO)
fluorescein 5-isothiocyanate  (ISO)
formaldehyde  (EXP,ISO)
furan  (ISO)
glyphosate  (ISO)
GW 4064  (ISO)
helenalin  (EXP)
hydroquinone  (EXP)
itraconazole  (EXP)
kaempferol  (EXP)
ketoconazole  (EXP)
lipopolysaccharide  (EXP,ISO)
Liranaftate  (EXP,ISO)
Luliconazole  (EXP)
Maxacalcitol  (ISO)
melatonin  (ISO)
methoxychlor  (ISO)
N-acetyl-L-cysteine  (EXP)
naringin  (EXP)
nickel dichloride  (EXP,ISO)
Nonylphenol  (ISO)
ozone  (ISO)
paracetamol  (EXP)
parthenolide  (EXP)
perfluorobutyric acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoropentanoic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (EXP)
phloxine O  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
poly(I:C)  (EXP)
progesterone  (EXP)
pyrrolidine dithiocarbamate  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 431542  (EXP)
serpentine asbestos  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
sunitinib  (EXP)
terbinafine  (EXP)
tetrachloromethane  (ISO)
thiram  (EXP)
toluene 2,4-diisocyanate  (EXP,ISO)
triclosan  (EXP,ISO)
valproic acid  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular region  (IBA,IDA,IEA,IMP,TAS)
extracellular space  (IDA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. TSLP Protects Corneas From Pseudomonas aeruginosa Infection by Regulating Dendritic Cells and IL-23-IL-17 Pathway. Cui X, etal., Invest Ophthalmol Vis Sci. 2018 Aug 1;59(10):4228-4237. doi: 10.1167/iovs.18-24672.
2. Interactions of thymic stromal lymphopoietin with TLR2 and TLR4 regulate anti-fungal innate immunity in Aspergillus fumigatus-induced corneal infection. Dai C, etal., Exp Eye Res. 2019 May;182:19-29. doi: 10.1016/j.exer.2019.02.020. Epub 2019 Mar 8.
3. Adjuvant selection for vaccination against murine schistosomiasis. El Ridi R and Tallima H, Scand J Immunol. 2012 Dec;76(6):552-8. doi: 10.1111/j.1365-3083.2012.02768.x.
4. Thymic stromal lymphopoietin, IL-33, and periostin in hospitalized infants with viral bronchiolitis. García-García ML, etal., Medicine (Baltimore). 2017 May;96(18):e6787. doi: 10.1097/MD.0000000000006787.
5. Thymic stromal lymphopoietin-dependent basophils promote Th2 cytokine responses following intestinal helminth infection. Giacomin PR, etal., J Immunol. 2012 Nov 1;189(9):4371-8. doi: 10.4049/jimmunol.1200691. Epub 2012 Sep 28.
6. The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice. Han M, etal., J Immunol. 2017 Aug 15;199(4):1308-1318. doi: 10.4049/jimmunol.1700216. Epub 2017 Jul 12.
7. Alteration of cytokine production during visceral larva migrans by Toxascaris leonina in mice. Kang SA, etal., Korean J Parasitol. 2013 Oct;51(5):583-8. doi: 10.3347/kjp.2013.51.5.583. Epub 2013 Oct 31.
8. Thymic stromal lymphopoietin mediates the host response and increases mortality during sepsis. Kuethe JW, etal., J Surg Res. 2014 Sep;191(1):19-24. doi: 10.1016/j.jss.2014.05.024. Epub 2014 May 20.
9. Phloxine O, a Cosmetic Colorant, Suppresses the Expression of Thymic Stromal Lymphopoietin and Acute Dermatitis Symptoms in Mice. Lee HE, etal., Biomol Ther (Seoul). 2018 Sep 1;26(5):481-486. doi: 10.4062/biomolther.2017.130.
10. Sex-associated TSLP-induced immune alterations following early-life RSV infection leads to enhanced allergic disease. Malinczak CA, etal., Mucosal Immunol. 2019 Jul;12(4):969-979. doi: 10.1038/s41385-019-0171-3. Epub 2019 May 11.
11. Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand, thymic stromal lymphopoietin, and IL-33. Mehta AK, etal., J Allergy Clin Immunol. 2016 Jan;137(1):278-88.e6. doi: 10.1016/j.jaci.2015.05.007. Epub 2015 Jun 19.
12. Itching in a trichophytin contact dermatitis mouse model and the antipruritic effect of antifungal agents. Nakamura T, etal., Clin Exp Dermatol. 2019 Jun;44(4):381-389. doi: 10.1111/ced.13719. Epub 2018 Sep 6.
13. Thymic Stromal Lymphopoietin Is Critical for Regulation of Proinflammatory Cytokine Response and Resistance to Experimental Trypanosoma congolense Infection. Onyilagha C, etal., Front Immunol. 2017 Jul 14;8:803. doi: 10.3389/fimmu.2017.00803. eCollection 2017.
14. Thymic Stromal Lymphopoietin Improves Survival and Reduces Inflammation in Sepsis. Piliponsky AM, etal., Am J Respir Cell Mol Biol. 2016 Aug;55(2):264-74. doi: 10.1165/rcmb.2015-0380OC.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. A potential link between TSLP/TSLPR/STAT5 and TLR2/MyD88/NFκB-p65 in human corneal epithelial cells for Aspergillus fumigatus tolerance. Ren X, etal., Mol Immunol. 2016 Mar;71:98-106. doi: 10.1016/j.molimm.2015.12.014. Epub 2016 Feb 11.
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Thymic stromal lymphopoietin in hepatitis C virus-related cryoglobulinemic vasculitis: gene expression level and protein distribution. Sansonno D, etal., Arthritis Res Ther. 2015 Mar 15;17:62. doi: 10.1186/s13075-015-0581-x.
19. Repurposing the psoriasis drug Oxarol to an ointment adjuvant for the influenza vaccine. Sato R, etal., Int Immunol. 2020 Jul 28;32(8):499-507. doi: 10.1093/intimm/dxaa012.
20. Oral interferon-alpha treatment of mice with cryoglobulinemic glomerulonephritis. Segerer S, etal., Am J Kidney Dis. 2002 Apr;39(4):876-88. doi: 10.1053/ajkd.2002.32011.
21. IL-25, IL-33 and TSLP receptor are not critical for development of experimental murine malaria. Shibui A, etal., Biochem Biophys Rep. 2015 Dec 14;5:191-195. doi: 10.1016/j.bbrep.2015.12.007. eCollection 2016 Mar.
22. Respiratory syncytial virus infection activates IL-13-producing group 2 innate lymphoid cells through thymic stromal lymphopoietin. Stier MT, etal., J Allergy Clin Immunol. 2016 Sep;138(3):814-824.e11. doi: 10.1016/j.jaci.2016.01.050. Epub 2016 Apr 9.
23. TSLP-activated dendritic cells induce T helper type 2 inflammation in Aspergillus fumigatus keratitis. Sun L, etal., Exp Eye Res. 2018 Jun;171:120-130. doi: 10.1016/j.exer.2018.03.014. Epub 2018 Mar 14.
24. TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis. Taylor BC, etal., J Exp Med. 2009 Mar 16;206(3):655-67. doi: 10.1084/jem.20081499. Epub 2009 Mar 9.
Additional References at PubMed
PMID:10570284   PMID:10881176   PMID:11418668   PMID:11480573   PMID:12055625   PMID:12477932   PMID:12707303   PMID:14999427   PMID:15741223   PMID:15944327   PMID:16432252   PMID:16782024  
PMID:16785889   PMID:16899198   PMID:17129180   PMID:17213320   PMID:17242164   PMID:17320941   PMID:17416344   PMID:17513456   PMID:17513717   PMID:17635955   PMID:17666213   PMID:17959543  
PMID:18049884   PMID:18060034   PMID:18244952   PMID:18445339   PMID:18450510   PMID:18482256   PMID:18684970   PMID:18720075   PMID:18757306   PMID:18768889   PMID:18787178   PMID:18802341  
PMID:18802347   PMID:18802348   PMID:18832669   PMID:18832690   PMID:18836588   PMID:18941246   PMID:19055649   PMID:19056108   PMID:19155513   PMID:19164348   PMID:19187393   PMID:19198610  
PMID:19231591   PMID:19348931   PMID:19400908   PMID:19423540   PMID:19539984   PMID:19555430   PMID:19561109   PMID:19741251   PMID:19763625   PMID:19770269   PMID:19841072   PMID:19857905  
PMID:19968632   PMID:20016474   PMID:20079130   PMID:20086239   PMID:20098747   PMID:20109311   PMID:20127673   PMID:20143171   PMID:20146705   PMID:20173030   PMID:20208534   PMID:20228393  
PMID:20236697   PMID:20300138   PMID:20335125   PMID:20406964   PMID:20438785   PMID:20444169   PMID:20444170   PMID:20466416   PMID:20501368   PMID:20538796   PMID:20555350   PMID:20560908  
PMID:20624642   PMID:20656951   PMID:20660708   PMID:20816195   PMID:20924287   PMID:20974963   PMID:21054781   PMID:21055671   PMID:21085187   PMID:21109412   PMID:21109746   PMID:21148792  
PMID:21178477   PMID:21244100   PMID:21255094   PMID:21274737   PMID:21439160   PMID:21440421   PMID:21458958   PMID:21463955   PMID:21468164   PMID:21576506   PMID:21682736   PMID:21689850  
PMID:21690322   PMID:21691053   PMID:21772055   PMID:21804548   PMID:21804549   PMID:21820713   PMID:21832049   PMID:21835441   PMID:21873635   PMID:21966427   PMID:21975173   PMID:22036096  
PMID:22092577   PMID:22154513   PMID:22168549   PMID:22189594   PMID:22274860   PMID:22304237   PMID:22317895   PMID:22355542   PMID:22442496   PMID:22578802   PMID:22633328   PMID:22750414  
PMID:22764833   PMID:22806096   PMID:22888172   PMID:22913730   PMID:22973903   PMID:22981788   PMID:23190696   PMID:23200753   PMID:23267211   PMID:23310954   PMID:23335246   PMID:23363980  
PMID:23376058   PMID:23413283   PMID:23433457   PMID:23485611   PMID:23495958   PMID:23602531   PMID:23688414   PMID:23817569   PMID:23817571   PMID:23872715   PMID:23953709   PMID:24028796  
PMID:24081992   PMID:24167583   PMID:24185116   PMID:24220317   PMID:24335833   PMID:24388013   PMID:24397611   PMID:24401911   PMID:24410591   PMID:24453244   PMID:24525665   PMID:24599138  
PMID:24652135   PMID:24698291   PMID:24773145   PMID:24782181   PMID:24792379   PMID:24794807   PMID:24831437   PMID:24850429   PMID:24888572   PMID:24910175   PMID:24930783   PMID:24931369  
PMID:24966899   PMID:25017104   PMID:25171086   PMID:25187315   PMID:25407941   PMID:25515628   PMID:25652868   PMID:25656998   PMID:25676453   PMID:25680454   PMID:25700684   PMID:25705788  
PMID:25763996   PMID:25817699   PMID:25962901   PMID:25979231   PMID:25981737   PMID:26014813   PMID:26026341   PMID:26095319   PMID:26175262   PMID:26288354   PMID:26419317   PMID:26531692  
PMID:26531761   PMID:26540312   PMID:26573878   PMID:26611474   PMID:26652578   PMID:26712523   PMID:26879860   PMID:26948075   PMID:26992000   PMID:26999524   PMID:27012942   PMID:27149122  
PMID:27152943   PMID:27187742   PMID:27304220   PMID:27385084   PMID:27429171   PMID:27494755   PMID:27503909   PMID:27528425   PMID:27634769   PMID:27697608   PMID:27744031   PMID:27769179  
PMID:27863334   PMID:27889082   PMID:27902816   PMID:27976427   PMID:27992078   PMID:27996052   PMID:28127565   PMID:28191908   PMID:28303765   PMID:28368013   PMID:28377574   PMID:28400057  
PMID:28443609   PMID:28479194   PMID:28545810   PMID:28615347   PMID:28631887   PMID:28655470   PMID:28720058   PMID:28746197   PMID:29272985   PMID:29320511   PMID:29453280   PMID:29631029  
PMID:29663593   PMID:29752758   PMID:29763522   PMID:29889228   PMID:30011850   PMID:30123216   PMID:30152851   PMID:30368785   PMID:30428724   PMID:30737962   PMID:30821220   PMID:31023965  
PMID:31066119   PMID:31089083   PMID:31139177   PMID:31210014   PMID:31217492   PMID:31290290   PMID:31352764   PMID:31378088   PMID:31387206   PMID:31491540   PMID:31556482   PMID:31682627  
PMID:31910693   PMID:31943442   PMID:32285594   PMID:32360270   PMID:32712161   PMID:32776912   PMID:32950025   PMID:33040302   PMID:33042121   PMID:33118609   PMID:33429916   PMID:33463103  
PMID:33486314   PMID:33535091   PMID:33836808   PMID:33879431   PMID:34081998   PMID:34111451   PMID:34147561   PMID:34153443   PMID:34299012   PMID:34326208   PMID:34331429   PMID:34440780  
PMID:34573368   PMID:34699696   PMID:34944487   PMID:35065132   PMID:35240143   PMID:35321112   PMID:35351157   PMID:36046760   PMID:36076269   PMID:36082495   PMID:36107619   PMID:36517245  
PMID:36694181   PMID:36726974   PMID:37030118   PMID:37096155   PMID:37364323   PMID:37422429   PMID:37500310   PMID:37515689   PMID:37628907   PMID:37640192   PMID:38081546   PMID:38172534  
PMID:38396704   PMID:38402021   PMID:38407489   PMID:38557942   PMID:38630260  


Genomics

Comparative Map Data
TSLP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385111,070,062 - 111,078,026 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5111,070,062 - 111,078,026 (+)EnsemblGRCh38hg38GRCh38
GRCh375110,405,760 - 110,413,724 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365110,435,289 - 110,441,623 (+)NCBINCBI36Build 36hg18NCBI36
Celera5106,353,329 - 106,359,661 (+)NCBICelera
Cytogenetic Map5q22.1NCBI
HuRef5105,584,896 - 105,592,841 (+)NCBIHuRef
CHM1_15109,839,103 - 109,847,047 (+)NCBICHM1_1
T2T-CHM13v2.05111,580,695 - 111,588,660 (+)NCBIT2T-CHM13v2.0
Tslp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391832,948,436 - 32,952,852 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1832,948,436 - 32,952,850 (+)EnsemblGRCm39 Ensembl
GRCm381832,815,383 - 32,819,799 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1832,815,383 - 32,819,797 (+)EnsemblGRCm38mm10GRCm38
MGSCv371832,975,037 - 32,979,453 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361832,958,393 - 32,962,802 (+)NCBIMGSCv36mm8
Celera1833,286,509 - 33,290,920 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.12NCBI
Tslp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81824,723,990 - 24,728,419 (+)NCBIGRCr8
mRatBN7.21824,447,409 - 24,454,244 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1824,449,844 - 24,453,548 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01825,613,601 - 25,618,066 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1825,613,831 - 25,617,361 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01825,326,396 - 25,333,230 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41825,268,082 - 25,274,214 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1824,198,059 - 24,202,524 (+)NCBICelera
Cytogenetic Map18p12NCBI
Tslp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554184,041,529 - 4,045,534 (-)NCBIChiLan1.0ChiLan1.0
TSLP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24106,340,561 - 106,348,525 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15104,494,184 - 104,502,180 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05106,440,136 - 106,446,849 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15112,242,490 - 112,249,200 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5112,242,490 - 112,250,130 (+)Ensemblpanpan1.1panPan2
TSLP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.131,502,469 - 1,507,696 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl31,503,188 - 1,507,696 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha32,907,296 - 2,971,755 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.031,393,149 - 1,400,425 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.131,339,901 - 1,404,345 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.031,341,683 - 1,348,998 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.031,506,469 - 1,571,642 (-)NCBIUU_Cfam_GSD_1.0
Tslp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213156,110,394 - 156,115,633 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365315,495,872 - 5,500,462 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSLP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.12115,832,152 - 115,837,572 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22120,289,894 - 120,323,977 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TSLP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12314,419,820 - 14,423,331 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603464,056,775 - 64,060,255 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in TSLP
10 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q15-22.3(chr5:96454445-114050905)x3 copy number gain See cases [RCV000051841] Chr5:96454445..114050905 [GRCh38]
Chr5:95790149..113386602 [GRCh37]
Chr5:95815905..113414501 [NCBI36]
Chr5:5q15-22.3
pathogenic
GRCh38/hg38 5q22.1(chr5:110564896-111731572)x3 copy number gain See cases [RCV000053289] Chr5:110564896..111731572 [GRCh38]
Chr5:109900597..111067269 [GRCh37]
Chr5:109928496..111095168 [NCBI36]
Chr5:5q22.1
uncertain significance
GRCh38/hg38 5q21.1-22.2(chr5:102373396-113594030)x1 copy number loss See cases [RCV000053523] Chr5:102373396..113594030 [GRCh38]
Chr5:101709100..112929727 [GRCh37]
Chr5:101736999..112957626 [NCBI36]
Chr5:5q21.1-22.2
pathogenic
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2
pathogenic
GRCh37/hg19 5q21.3-22.1(chr5:108634380-110629961)x3 copy number gain See cases [RCV003221777] Chr5:108634380..110629961 [GRCh37]
Chr5:5q21.3-22.1
uncertain significance
GRCh38/hg38 5q21.3-23.1(chr5:108585264-116815075)x1 copy number loss See cases [RCV000133813] Chr5:108585264..116815075 [GRCh38]
Chr5:107920965..116150771 [GRCh37]
Chr5:107948864..116178670 [NCBI36]
Chr5:5q21.3-23.1
pathogenic
GRCh38/hg38 5q21.3-23.1(chr5:107002209-118025316)x1 copy number loss See cases [RCV000135699] Chr5:107002209..118025316 [GRCh38]
Chr5:106337910..117361011 [GRCh37]
Chr5:106365809..117388910 [NCBI36]
Chr5:5q21.3-23.1
pathogenic
GRCh38/hg38 5q22.1-23.3(chr5:110687442-130103838)x1 copy number loss See cases [RCV000139235] Chr5:110687442..130103838 [GRCh38]
Chr5:110023143..129439531 [GRCh37]
Chr5:110051042..129467430 [NCBI36]
Chr5:5q22.1-23.3
pathogenic|uncertain significance
GRCh38/hg38 5q14.3-23.3(chr5:90374606-128076423)x1 copy number loss See cases [RCV000139893] Chr5:90374606..128076423 [GRCh38]
Chr5:89670423..127412115 [GRCh37]
Chr5:89706179..127440014 [NCBI36]
Chr5:5q14.3-23.3
pathogenic
GRCh38/hg38 5q14.3-22.1(chr5:84603580-111435081)x1 copy number loss See cases [RCV000139656] Chr5:84603580..111435081 [GRCh38]
Chr5:83899398..110770779 [GRCh37]
Chr5:83935154..110798678 [NCBI36]
Chr5:5q14.3-22.1
pathogenic
GRCh38/hg38 5q14.3-23.1(chr5:92899734-119614119)x1 copy number loss See cases [RCV000141252] Chr5:92899734..119614119 [GRCh38]
Chr5:92235441..118949814 [GRCh37]
Chr5:92261197..118977713 [NCBI36]
Chr5:5q14.3-23.1
pathogenic
GRCh38/hg38 5q22.1(chr5:110469276-111738442)x1 copy number loss See cases [RCV000141870] Chr5:110469276..111738442 [GRCh38]
Chr5:109804977..111074139 [GRCh37]
Chr5:109832876..111102038 [NCBI36]
Chr5:5q22.1
uncertain significance
GRCh38/hg38 5q21.3-22.2(chr5:106586078-113006585)x1 copy number loss See cases [RCV000142171] Chr5:106586078..113006585 [GRCh38]
Chr5:105921779..112342282 [GRCh37]
Chr5:105949678..112370181 [NCBI36]
Chr5:5q21.3-22.2
pathogenic
GRCh38/hg38 5q21.3-23.2(chr5:108308463-125777797)x1 copy number loss See cases [RCV000143326] Chr5:108308463..125777797 [GRCh38]
Chr5:107644164..125113490 [GRCh37]
Chr5:107672063..125141389 [NCBI36]
Chr5:5q21.3-23.2
pathogenic
GRCh38/hg38 5q15-22.2(chr5:93193104-113287795)x1 copy number loss See cases [RCV000143249] Chr5:93193104..113287795 [GRCh38]
Chr5:92528810..112623492 [GRCh37]
Chr5:92554566..112651391 [NCBI36]
Chr5:5q15-22.2
pathogenic
GRCh38/hg38 5q14.3-31.1(chr5:91411708-131319563)x1 copy number loss See cases [RCV000143746] Chr5:91411708..131319563 [GRCh38]
Chr5:90707525..130655256 [GRCh37]
Chr5:90743281..130683155 [NCBI36]
Chr5:5q14.3-31.1
pathogenic
GRCh37/hg19 5q21.3-22.1(chr5:109438167-110644401)x3 copy number gain See cases [RCV000240422] Chr5:109438167..110644401 [GRCh37]
Chr5:5q21.3-22.1
uncertain significance
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3
likely benign
GRCh37/hg19 5q22.1-23.2(chr5:110407606-122522885)x1 copy number loss See cases [RCV000446959] Chr5:110407606..122522885 [GRCh37]
Chr5:5q22.1-23.2
pathogenic
GRCh37/hg19 5q21.1-23.2(chr5:100607918-125900735)x1 copy number loss See cases [RCV000445968] Chr5:100607918..125900735 [GRCh37]
Chr5:5q21.1-23.2
pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3
pathogenic
GRCh37/hg19 5q21.3-22.1(chr5:109146807-111474789)x4 copy number gain See cases [RCV000510369] Chr5:109146807..111474789 [GRCh37]
Chr5:5q21.3-22.1
uncertain significance
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q21.3-22.1(chr5:108604653-110636716)x4 copy number gain See cases [RCV000510996] Chr5:108604653..110636716 [GRCh37]
Chr5:5q21.3-22.1
uncertain significance
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV004561496]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2
pathogenic
GRCh37/hg19 5q22.1(chr5:110234471-110761241)x3 copy number gain not provided [RCV000682589] Chr5:110234471..110761241 [GRCh37]
Chr5:5q22.1
uncertain significance
GRCh37/hg19 5q21.3-23.1(chr5:108304806-121335239)x1 copy number loss not provided [RCV000846246] Chr5:108304806..121335239 [GRCh37]
Chr5:5q21.3-23.1
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q22.1(chr5:110345020-110419888)x1 copy number loss not provided [RCV000745051] Chr5:110345020..110419888 [GRCh37]
Chr5:5q22.1
benign
GRCh37/hg19 5q22.1(chr5:110345020-110427347)x1 copy number loss not provided [RCV000745052] Chr5:110345020..110427347 [GRCh37]
Chr5:5q22.1
benign
GRCh37/hg19 5q22.1(chr5:110413489-110441839)x3 copy number gain not provided [RCV000745053] Chr5:110413489..110441839 [GRCh37]
Chr5:5q22.1
benign
GRCh37/hg19 5q22.1(chr5:110413489-110445893)x3 copy number gain not provided [RCV000745054] Chr5:110413489..110445893 [GRCh37]
Chr5:5q22.1
benign
GRCh37/hg19 5q22.1(chr5:110413489-110447853)x3 copy number gain not provided [RCV000745055] Chr5:110413489..110447853 [GRCh37]
Chr5:5q22.1
benign
GRCh37/hg19 5q22.1(chr5:110413489-110448313)x3 copy number gain not provided [RCV000745056] Chr5:110413489..110448313 [GRCh37]
Chr5:5q22.1
benign
GRCh37/hg19 5q22.1(chr5:110413489-110450584)x3 copy number gain not provided [RCV000745057] Chr5:110413489..110450584 [GRCh37]
Chr5:5q22.1
benign
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32
uncertain significance
GRCh37/hg19 5q14.3-23.3(chr5:89949118-129317455)x3 copy number gain not provided [RCV000849289] Chr5:89949118..129317455 [GRCh37]
Chr5:5q14.3-23.3
pathogenic
GRCh37/hg19 5q22.1(chr5:109786744-110813071)x1 copy number loss not provided [RCV002473447] Chr5:109786744..110813071 [GRCh37]
Chr5:5q22.1
uncertain significance
GRCh37/hg19 5q22.1(chr5:110338499-110668272)x3 copy number gain not provided [RCV001259353] Chr5:110338499..110668272 [GRCh37]
Chr5:5q22.1
uncertain significance
GRCh37/hg19 5q15-22.3(chr5:93650000-114969108) copy number loss not specified [RCV002053511] Chr5:93650000..114969108 [GRCh37]
Chr5:5q15-22.3
pathogenic
GRCh37/hg19 5q21.1-23.2(chr5:100607918-125900735) copy number loss not specified [RCV002053515] Chr5:100607918..125900735 [GRCh37]
Chr5:5q21.1-23.2
pathogenic
GRCh37/hg19 5q22.1(chr5:110299633-110427052)x1 copy number loss not provided [RCV001833000] Chr5:110299633..110427052 [GRCh37]
Chr5:5q22.1
likely benign
NM_033035.5(TSLP):c.103G>A (p.Asp35Asn) single nucleotide variant not specified [RCV004309145] Chr5:111071993 [GRCh38]
Chr5:110407691 [GRCh37]
Chr5:5q22.1
uncertain significance
NM_033035.5(TSLP):c.181A>G (p.Thr61Ala) single nucleotide variant not specified [RCV004211962] Chr5:111072897 [GRCh38]
Chr5:110408595 [GRCh37]
Chr5:5q22.1
uncertain significance
NM_033035.5(TSLP):c.418C>A (p.Gln140Lys) single nucleotide variant not specified [RCV004236235] Chr5:111076012 [GRCh38]
Chr5:110411710 [GRCh37]
Chr5:5q22.1
uncertain significance
NM_033035.5(TSLP):c.70G>C (p.Gly24Arg) single nucleotide variant not specified [RCV004172194] Chr5:111071960 [GRCh38]
Chr5:110407658 [GRCh37]
Chr5:5q22.1
uncertain significance
NM_033035.5(TSLP):c.275C>G (p.Ser92Trp) single nucleotide variant not specified [RCV004110082] Chr5:111073569 [GRCh38]
Chr5:110409267 [GRCh37]
Chr5:5q22.1
uncertain significance
NM_033035.5(TSLP):c.203C>G (p.Ser68Cys) single nucleotide variant not specified [RCV004285397] Chr5:111072919 [GRCh38]
Chr5:110408617 [GRCh37]
Chr5:5q22.1
uncertain significance
NM_033035.5(TSLP):c.108T>G (p.Phe36Leu) single nucleotide variant not specified [RCV004323388] Chr5:111071998 [GRCh38]
Chr5:110407696 [GRCh37]
Chr5:5q22.1
uncertain significance
NM_033035.5(TSLP):c.35T>A (p.Val12Asp) single nucleotide variant not specified [RCV004335757] Chr5:111071925 [GRCh38]
Chr5:110407623 [GRCh37]
Chr5:5q22.1
uncertain significance
GRCh37/hg19 5q22.1(chr5:110328036-110438929)x1 copy number loss not provided [RCV003485473] Chr5:110328036..110438929 [GRCh37]
Chr5:5q22.1
uncertain significance
GRCh37/hg19 5q22.1(chr5:110371834-110456849)x1 copy number loss not provided [RCV003485475] Chr5:110371834..110456849 [GRCh37]
Chr5:5q22.1
uncertain significance
Single allele deletion not provided [RCV003448698] Chr5:106137712..111825745 [GRCh37]
Chr5:5q21.3-22.2
uncertain significance
GRCh37/hg19 5q15-23.2(chr5:93828571-123711334)x1 copy number loss not specified [RCV003986577] Chr5:93828571..123711334 [GRCh37]
Chr5:5q15-23.2
pathogenic
NM_033035.5(TSLP):c.410G>C (p.Cys137Ser) single nucleotide variant not specified [RCV004476573] Chr5:111076004 [GRCh38]
Chr5:110411702 [GRCh37]
Chr5:5q22.1
uncertain significance
NM_033035.5(TSLP):c.394G>C (p.Val132Leu) single nucleotide variant not specified [RCV004680429] Chr5:111075988 [GRCh38]
Chr5:110411686 [GRCh37]
Chr5:5q22.1
uncertain significance
NM_033035.5(TSLP):c.445C>T (p.Arg149Cys) single nucleotide variant not specified [RCV004680430] Chr5:111076039 [GRCh38]
Chr5:110411737 [GRCh37]
Chr5:5q22.1
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:937
Count of miRNA genes:509
Interacting mature miRNAs:571
Transcripts:ENST00000344895, ENST00000379706, ENST00000420978
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407271044GWAS920020_Hasthma QTL GWAS920020 (human)3e-26asthma5111071044111071045Human
406923491GWAS572467_Hatopic asthma QTL GWAS572467 (human)8e-12atopic asthma5111073450111073451Human
406962114GWAS611090_Heosinophilic esophagitis QTL GWAS611090 (human)2e-08eosinophilic esophagitis5111071044111071045Human
407000490GWAS649466_Hadult onset asthma QTL GWAS649466 (human)1e-22adult onset asthma5111072304111072305Human
407363372GWAS1012348_HGlucocorticoid use measurement QTL GWAS1012348 (human)8e-20Glucocorticoid use measurement5111072304111072305Human
406923500GWAS572476_Hatopic asthma QTL GWAS572476 (human)2e-11atopic asthma5111071809111071810Human
407300182GWAS949158_Hasthma, age at onset QTL GWAS949158 (human)8e-10asthma, age at onset5111072304111072305Human
407023665GWAS672641_Hseasonal allergic rhinitis QTL GWAS672641 (human)0.000005seasonal allergic rhinitis5111072304111072305Human
407150290GWAS799266_Hchildhood onset asthma QTL GWAS799266 (human)2e-08childhood onset asthma5111073450111073451Human
407300222GWAS949198_Hasthma QTL GWAS949198 (human)1e-38asthma5111072304111072305Human
407259484GWAS908460_Hasthma QTL GWAS908460 (human)1e-14asthma5111071044111071045Human
407017048GWAS666024_HGlucocorticoid use measurement QTL GWAS666024 (human)8e-17Glucocorticoid use measurement5111072304111072305Human
407255064GWAS904040_Heosinophil count QTL GWAS904040 (human)2e-29eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)5111072304111072305Human

Markers in Region
RH102180  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375110,412,042 - 110,412,229UniSTSGRCh37
Build 365110,439,941 - 110,440,128RGDNCBI36
Celera5106,357,981 - 106,358,168RGD
Cytogenetic Map5q22.1UniSTS
HuRef5105,591,161 - 105,591,348UniSTS
GeneMap99-GB4 RH Map5465.41UniSTS
TSLP_1555  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375110,411,708 - 110,412,556UniSTSGRCh37
Build 365110,439,607 - 110,440,455RGDNCBI36
Celera5106,357,647 - 106,358,495RGD
HuRef5105,590,827 - 105,591,675UniSTS
RH65594  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375110,406,031 - 110,406,166UniSTSGRCh37
Build 365110,433,930 - 110,434,065RGDNCBI36
Celera5106,351,970 - 106,352,105RGD
Cytogenetic Map5q22.1UniSTS
HuRef5105,585,149 - 105,585,284UniSTS
GeneMap99-GB4 RH Map5462.97UniSTS
NCBI RH Map5772.0UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_033035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_138551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_045089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011543698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047417846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047417847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054353732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054353733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC008572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF338732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL833421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY037115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF245025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU571002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS390620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS403714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB735793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GN090295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HD117895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HH762798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000344895   ⟹   ENSP00000339804
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5111,071,713 - 111,078,026 (+)Ensembl
Ensembl Acc Id: ENST00000379706   ⟹   ENSP00000427827
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5111,073,314 - 111,078,024 (+)Ensembl
Ensembl Acc Id: ENST00000420978   ⟹   ENSP00000399099
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5111,070,062 - 111,076,793 (+)Ensembl
RefSeq Acc Id: NM_033035   ⟹   NP_149024
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385111,071,713 - 111,078,026 (+)NCBI
GRCh375110,405,778 - 110,413,722 (+)NCBI
Build 365110,435,289 - 110,441,623 (+)NCBI Archive
HuRef5105,584,896 - 105,592,841 (+)NCBI
CHM1_15109,840,715 - 109,847,047 (+)NCBI
T2T-CHM13v2.05111,582,346 - 111,588,660 (+)NCBI
Sequence:
RefSeq Acc Id: NM_138551   ⟹   NP_612561
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385111,073,374 - 111,078,026 (+)NCBI
GRCh375110,405,778 - 110,413,722 (+)NCBI
Build 365110,436,925 - 110,441,623 (+)NCBI Archive
HuRef5105,584,896 - 105,592,841 (+)NCBI
CHM1_15109,842,337 - 109,847,047 (+)NCBI
T2T-CHM13v2.05111,584,007 - 111,588,660 (+)NCBI
Sequence:
RefSeq Acc Id: NR_045089
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385111,070,062 - 111,078,026 (+)NCBI
GRCh375110,405,778 - 110,413,722 (+)NCBI
HuRef5105,584,896 - 105,592,841 (+)NCBI
CHM1_15109,839,103 - 109,847,047 (+)NCBI
T2T-CHM13v2.05111,580,695 - 111,588,660 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011543698   ⟹   XP_011542000
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385111,073,323 - 111,078,026 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047417846   ⟹   XP_047273802
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385111,071,713 - 111,078,026 (+)NCBI
RefSeq Acc Id: XM_047417847   ⟹   XP_047273803
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385111,070,090 - 111,078,026 (+)NCBI
RefSeq Acc Id: XM_054353732   ⟹   XP_054209707
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05111,580,723 - 111,588,660 (+)NCBI
RefSeq Acc Id: XM_054353733   ⟹   XP_054209708
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05111,583,956 - 111,588,660 (+)NCBI
RefSeq Acc Id: NP_149024   ⟸   NM_033035
- Peptide Label: isoform 1 precursor
- UniProtKB: Q8IW99 (UniProtKB/Swiss-Prot),   G3XAM8 (UniProtKB/Swiss-Prot),   Q96AU7 (UniProtKB/Swiss-Prot),   Q969D9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_612561   ⟸   NM_138551
- Peptide Label: isoform 2
- UniProtKB: Q969D9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011542000   ⟸   XM_011543698
- Peptide Label: isoform X3
- UniProtKB: Q969D9 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000427827   ⟸   ENST00000379706
Ensembl Acc Id: ENSP00000399099   ⟸   ENST00000420978
Ensembl Acc Id: ENSP00000339804   ⟸   ENST00000344895
RefSeq Acc Id: XP_047273803   ⟸   XM_047417847
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047273802   ⟸   XM_047417846
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054209707   ⟸   XM_054353732
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054209708   ⟸   XM_054353733
- Peptide Label: isoform X3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q969D9-F1-model_v2 AlphaFold Q969D9 1-159 view protein structure

Promoters
RGD ID:6803621
Promoter ID:HG_KWN:50808
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562
Transcripts:NR_033425
Position:
Human AssemblyChrPosition (strand)Source
Build 365110,436,659 - 110,437,159 (+)MPROMDB
RGD ID:6870238
Promoter ID:EPDNEW_H8284
Type:multiple initiation site
Name:TSLP_2
Description:thymic stromal lymphopoietin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H8285  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh385111,071,713 - 111,071,773EPDNEW
RGD ID:6870240
Promoter ID:EPDNEW_H8285
Type:initiation region
Name:TSLP_1
Description:thymic stromal lymphopoietin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H8284  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh385111,073,374 - 111,073,434EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:30743 AgrOrtholog
COSMIC TSLP COSMIC
Ensembl Genes ENSG00000145777 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000344895 ENTREZGENE
  ENST00000344895.4 UniProtKB/Swiss-Prot
  ENST00000379706 ENTREZGENE
  ENST00000379706.4 UniProtKB/Swiss-Prot
  ENST00000420978.6 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000145777 GTEx
HGNC ID HGNC:30743 ENTREZGENE
Human Proteome Map TSLP Human Proteome Map
InterPro TSLP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSLP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:85480 UniProtKB/Swiss-Prot
NCBI Gene 85480 ENTREZGENE
OMIM 607003 OMIM
PANTHER PTHR38003 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYMIC STROMAL LYMPHOPOIETIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TSLP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA162407159 PharmGKB
UniProt A0A0C4DG43_HUMAN UniProtKB/TrEMBL
  G3XAM8 ENTREZGENE
  Q8IW99 ENTREZGENE
  Q969D9 ENTREZGENE
  Q96AU7 ENTREZGENE
  TSLP_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary G3XAM8 UniProtKB/Swiss-Prot
  Q8IW99 UniProtKB/Swiss-Prot
  Q96AU7 UniProtKB/Swiss-Prot