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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1621551
Species: Mus musculus
RGD Object: Gene
Symbol: Pmaip1
Name: phorbol-12-myristate-13-acetate-induced protein 1
Acc ID: CHEBI:72564
Term: temozolomide
Definition: An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma.
Chemical ID: MESH:C047246
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pmaip1increases expressionISOPMAIP1 (Homo sapiens)6480464CTDTemozolomide results in increased expression of PMAIP1 mRNAPMID:31758290
Pmaip1multiple interactionsISOPMAIP1 (Homo sapiens)6480464CTD[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in decreased expression of PMAIP1 mRNA; TP53 protein promotes the reaction [Temozolomide results in increased expression of PMAIP1 mRNA]PMID:17216584 PMID:32800223
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