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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1619654
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt1a5
Name: UDP glucuronosyltransferase 1 family, polypeptide A5
Acc ID: CHEBI:47499
Term: imipramine
Definition: A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Chemical ID: MESH:D007099
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a5affects metabolic processingISOUGT1A4 (Homo sapiens)6480464CTDUGT1A4 protein affects the metabolism of ImipraminePMID:15286053
Ugt1a5increases glucuronidationISOUGT1A4 (Homo sapiens)6480464CTDUGT1A4 protein results in increased glucuronidation of Imipramine; UGT1A4 protein SNP results in increased glucuronidation of ImipraminePMID:14570768 PMID:15708967 PMID:25448279 PMID:9264550
Ugt1a5multiple interactionsISOUGT1A4 (Homo sapiens)6480464CTDFinasteride inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Imipramine]PMID:25448279
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