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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1615570
Species: Mus musculus
RGD Object: Gene
Symbol: Syne2
Name: spectrin repeat containing, nuclear envelope 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Syne2decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of SYNE2 mRNAPMID:21715664
Syne2decreases methylationEXP 6480464CTDBenzo(a)pyrene results in decreased methylation of SYNE2 exon; Benzo(a)pyrene results in decreased methylation of SYNE2 intronPMID:27901495
Syne2multiple interactionsEXP 6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SYNE2 mRNAPMID:27858113
Syne2affects methylationISOSYNE2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of SYNE2 3' UTR; Benzo(a)pyrene affects the methylation of SYNE2 intronPMID:27901495 PMID:30157460
Syne2decreases expressionISOSYNE2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of SYNE2 mRNAPMID:22316170 PMID:26238291
Syne2decreases methylationISOSYNE2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of SYNE2 promoterPMID:27901495
Syne2increases methylationISOSYNE2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of SYNE2 5' UTR; Benzo(a)pyrene results in increased methylation of SYNE2 exonPMID:27901495
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