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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1607086
Species: Homo sapiens
RGD Object: Gene
Symbol: SKP2
Name: S-phase kinase associated protein 2
Acc ID: CHEBI:63632
Term: topotecan
Definition: A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.
Chemical ID: MESH:D019772
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SKP2affects response to substanceEXP 6480464CTDSKP2 protein affects the susceptibility to TopotecanPMID:16217747
SKP2multiple interactionsISOSkp2 (Rattus norvegicus)6480464CTD[oxaliplatin co-treated with Topotecan] results in decreased expression of SKP2 mRNAPMID:25729387
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