Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	1607086
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	SKP2
Name:	S-phase kinase associated protein 2

Acc ID:	CHEBI:16469
Term:	17beta-estradiol
Definition:	The 17beta-isomer of estradiol.
Chemical ID:	MESH:D004958

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
SKP2	increases expression	EXP		6480464	CTD	Estradiol results in increased expression of SKP2 protein	PMID:23029392
SKP2	increases response to substance	EXP		6480464	CTD	SKP2 protein results in increased susceptibility to Estradiol	PMID:23029392
SKP2	multiple interactions	EXP		6480464	CTD	[Estradiol co-treated with TGFB1 protein] results in decreased expression of SKP2 mRNA; [Progesterone co-treated with Estradiol] results in decreased expression of SKP2 protein; lactacystin inhibits the reaction [Estradiol results in increased expression of SKP2 protein]; SKP2 mutant form inhibits the reaction [Estradiol results in increased degradation of CDKN1B protein]	PMID:23029392 PMID:30165855
SKP2	increases expression	ISO	Skp2 (Rattus norvegicus)	6480464	CTD	Estradiol results in increased expression of SKP2 mRNA	PMID:32145629

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