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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1604985
Species: Homo sapiens
RGD Object: Gene
Symbol: KLB
Name: klotho beta
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KLBdecreases expressionEXP 6480464CTDAflatoxin B1 results in decreased expression of KLB mRNAPMID:21641981 PMID:22100608 PMID:27153756
KLBdecreases methylationEXP 6480464CTDAflatoxin B1 results in decreased methylation of KLB genePMID:27153756
KLBdecreases expressionISOKlb (Mus musculus)6480464CTDAflatoxin B1 results in decreased expression of KLB mRNAPMID:19770486
KLBincreases expressionISOKlb (Rattus norvegicus)6480464CTDAflatoxin B1 results in increased expression of KLB mRNAPMID:33354967
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