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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1594531
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prdm2
Name: PR/SET domain 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prdm2decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of PRDM2 mRNAPMID:32145629
Prdm2increases expressionEXP 6480464CTDbisphenol A results in increased expression of PRDM2 mRNAPMID:25181051
Prdm2increases methylationEXP 6480464CTDbisphenol A results in increased methylation of PRDM2 genePMID:28505145
Prdm2affects splicingISOPrdm2 (Mus musculus)6480464CTDbisphenol A affects the splicing of PRDM2 mRNAPMID:37894381
Prdm2increases expressionISOPRDM2 (Homo sapiens)6480464CTDbisphenol A results in increased expression of PRDM2 mRNAPMID:28765096
Prdm2multiple interactionsISOPRDM2 (Homo sapiens)6480464CTD[bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PRDM2 protein modified form]; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PRDM2 mRNA; bisphenol A inhibits the reaction [ESR1 protein binds to PRDM2 protein]PMID:28628672 PMID:28751236 PMID:29389661
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