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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1592221
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mlkl
Name: mixed lineage kinase domain like pseudokinase
Acc ID: CHEBI:2948
Term: azathioprine
Definition: A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Chemical ID: MESH:D001379
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mlkldecreases expressionISOMLKL (Homo sapiens)6480464CTDAzathioprine results in decreased expression of MLKL mRNAPMID:22623647
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