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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1592081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mpo
Name: myeloperoxidase
Acc ID: CHEBI:3435
Term: carrageenan
Definition: A family of sulfated polysaccharides extracted from red seaweeds. The name is derived from a common name of red algae Chondrus crispus, 'carrageen moss' (Irish moss).
Chemical ID: MESH:D002351
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mpoincreases activityEXP 6480464CTDCarrageenan results in increased activity of MPO proteinPMID:15860553 PMID:18429935 PMID:23872256 PMID:24412305 PMID:9890637
Mpoincreases expressionEXP 6480464CTDCarrageenan results in increased expression of MPO mRNA; Carrageenan results in increased expression of MPO proteinPMID:25451575 PMID:34789018
Mpomultiple interactionsEXP 6480464CTDadelmidrol inhibits the reaction [Carrageenan results in increased activity of MPO protein]; arvelexin analog inhibits the reaction [Carrageenan results in increased expression of MPO protein]; caffeic acid phenethyl ester inhibits the reaction [Carrageenan results in increased expression of MPO mRNA]; Carrageenan inhibits the reaction [Raloxifene Hydrochloride results in increased activity of MPO protein]; Dexamethasone inhibits the reaction [Carrageenan results in increased activity of MPO protein]; Diclofenac inhibits the reaction [Carrageenan results in increased activity of MPO protein]; Ibuprofen inhibits the reaction [Carrageenan results in increased expression of MPO protein]; Indomethacin inhibits the reaction [Carrageenan results in increased expression of MPO mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Carrageenan results in increased activity of MPO protein]; N-(2-hydroxybenzoyl)tyramine inhibits the reaction [Carrageenan results in increased activity of MPO protein]; Thiazolidines analog inhibits the reaction [Carrageenan results in increased activity of MPO protein]PMID:15860553 PMID:18429935 PMID:23872256 PMID:24412305 PMID:25451575 PMID:34789018 PMID:9890637
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