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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1589798
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gys1
Name: glycogen synthase 1
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gys1decreases expressionEXP 6480464CTDStreptozocin results in decreased expression of GYS1 mRNAPMID:27038876
Gys1increases phosphorylationEXP 6480464CTDStreptozocin results in increased phosphorylation of GYS1 proteinPMID:36627075
Gys1multiple interactionsEXP 6480464CTDPlant Extracts inhibits the reaction [Streptozocin results in decreased expression of GYS1 mRNA]; Tribulus extract inhibits the reaction [Streptozocin results in increased phosphorylation of GYS1 protein]PMID:27038876 PMID:36627075
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