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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1589743
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ulk1
Name: unc-51 like autophagy activating kinase 1
Acc ID: CHEBI:3944
Term: cucurbitacin E
Definition: A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 1, 5 and 23.
Chemical ID: MESH:C102326
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ulk1multiple interactionsISOULK1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [cucurbitacin E results in decreased expression of and results in decreased phosphorylation of ULK1 protein]; cucurbitacin E results in decreased expression of and results in decreased phosphorylation of ULK1 proteinPMID:27106530
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