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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1589591
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif2a
Name: eukaryotic translation initiation factor 2A
Acc ID: CHEBI:3764
Term: clotrimazole
Definition: A member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to a nitrogen is replaced by a monochlorotrityl group.
Chemical ID: MESH:D003022
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2aincreases phosphorylationISOEIF2A (Homo sapiens)6480464CTDClotrimazole results in increased phosphorylation of EIF2A proteinPMID:23405127
Eif2amultiple interactionsISOEIF2A (Homo sapiens)6480464CTD[Clotrimazole results in increased phosphorylation of EIF2A protein] which results in increased expression of TMEFF2 proteinPMID:23405127
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