EIF2A (eukaryotic translation initiation factor 2A) - Rat Genome Database
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Gene: EIF2A (eukaryotic translation initiation factor 2A) Homo sapiens
Analyze
Symbol: EIF2A
Name: eukaryotic translation initiation factor 2A
RGD ID: 1605026
HGNC Page HGNC
Description: Exhibits ribosome binding activity; tRNA binding activity; and translation initiation factor activity. Involved in regulation of translation and ribosome assembly. Localizes to eukaryotic translation initiation factor 2 complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 65 kDa eukaryotic translation initiation factor 2A; CDA02; EIF-2A; eukaryotic translation initiation factor 2A, 65kDa; MST089; MSTP004; MSTP089
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: EIF2AP1   EIF2AP2   EIF2AP3   EIF2AP4  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: EIF2A (Gene ID: 83939) and EIF2S1 (Gene ID: 1965) share the EIF2A symbol/alias in common. EIF2A is a widely used alternative name for eukaryotic translation initiation factor 2 subunit alpha (EIF2S1), which can be confused with the official symbol for eukaryotic translation initiation factor 2A (EIF2A). [05 Jul 2018]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3150,546,678 - 150,586,016 (+)EnsemblGRCh38hg38GRCh38
GRCh383150,546,726 - 150,586,016 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373150,264,465 - 150,303,803 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh373150,264,574 - 150,303,803 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363151,747,264 - 151,786,493 (+)NCBINCBI36hg18NCBI36
Celera3148,677,477 - 148,716,838 (+)NCBI
Cytogenetic Map3q25.1NCBI
HuRef3147,638,280 - 147,677,485 (+)NCBIHuRef
CHM1_13150,227,518 - 150,266,862 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (EXP)
(R)-lipoic acid  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
15-acetyldeoxynivalenol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (ISO)
3-acetyldeoxynivalenol  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP,ISO)
amiloride  (ISO)
amiodarone  (EXP,ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bepridil  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
borrelidin  (EXP)
bortezomib  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (EXP)
capsaicin  (EXP,ISO)
carbamazepine  (EXP)
cerulenin  (EXP)
chloroacetic acid  (ISO)
chloropicrin  (EXP)
cibenzoline  (EXP)
ciglitazone  (EXP)
cisplatin  (EXP,ISO)
clotrimazole  (EXP)
cordycepin  (ISO)
cycloheximide  (EXP)
cyclosporin A  (EXP)
deoxynivalenol  (EXP)
diarsenic trioxide  (EXP,ISO)
diclofenac  (EXP)
dicrotophos  (EXP)
dioxygen  (ISO)
doxorubicin  (EXP)
ethanol  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
Fusarenone X  (EXP)
L-1,4-dithiothreitol  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (ISO)
meglumine amidotrizoate  (ISO)
methylseleninic acid  (EXP)
N-acetyl-L-cysteine  (ISO)
nefazodone  (EXP)
nelfinavir  (EXP)
nicotinic acid  (ISO)
Niflumic acid  (EXP)
Nivalenol  (EXP)
nonivamide  (EXP)
orlistat  (EXP,ISO)
ouabain  (EXP)
oxidopamine  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
platycodin D  (EXP)
pterostilbene  (EXP)
quercetin  (EXP)
reactive oxygen species  (ISO)
salubrinal  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sorafenib  (EXP)
sunitinib  (EXP)
tamibarotene  (EXP)
tetrachloroethene  (ISO)
thapsigargin  (EXP,ISO)
Tiron  (ISO)
Tributyltin oxide  (ISO)
tunicamycin  (EXP,ISO)
valdecoxib  (ISO)
valproic acid  (EXP)
vitamin E  (EXP)
vorinostat  (EXP)
withaferin A  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:1620067   PMID:12133843   PMID:12477932   PMID:14702039   PMID:15475356   PMID:15718232   PMID:15781241   PMID:15961545   PMID:16344560   PMID:17274640   PMID:17407708   PMID:18337511  
PMID:19229320   PMID:19913121   PMID:20434207   PMID:20628086   PMID:20706999   PMID:21745818   PMID:21832049   PMID:21873635   PMID:22516433   PMID:22664934   PMID:22863883   PMID:22939629  
PMID:23443559   PMID:25468996   PMID:25544563   PMID:25852190   PMID:25921289   PMID:26186194   PMID:26344197   PMID:26777405   PMID:27025967   PMID:27609520   PMID:27634302   PMID:28240315  
PMID:28514442   PMID:28515276   PMID:28675297   PMID:28718761   PMID:28986522   PMID:29070839   PMID:29207036   PMID:29233968   PMID:29395067   PMID:29467282   PMID:29486283   PMID:29568061  
PMID:29802200   PMID:29955894   PMID:29991528   PMID:30084053   PMID:30196744   PMID:30209976   PMID:30723157   PMID:30747823   PMID:30997501   PMID:31023583   PMID:31059266   PMID:31086176  
PMID:31091453   PMID:31452512   PMID:31527615   PMID:31685988   PMID:31847234   PMID:31894250   PMID:31913484   PMID:31980649   PMID:32416067   PMID:32457219   PMID:32788342  


Genomics

Comparative Map Data
EIF2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3150,546,678 - 150,586,016 (+)EnsemblGRCh38hg38GRCh38
GRCh383150,546,726 - 150,586,016 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373150,264,465 - 150,303,803 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh373150,264,574 - 150,303,803 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363151,747,264 - 151,786,493 (+)NCBINCBI36hg18NCBI36
Celera3148,677,477 - 148,716,838 (+)NCBI
Cytogenetic Map3q25.1NCBI
HuRef3147,638,280 - 147,677,485 (+)NCBIHuRef
CHM1_13150,227,518 - 150,266,862 (+)NCBICHM1_1
Eif2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39358,433,242 - 58,464,922 (+)NCBIGRCm39mm39
GRCm38358,525,821 - 58,557,501 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl358,525,821 - 58,557,501 (+)EnsemblGRCm38mm10GRCm38
MGSCv37358,329,743 - 58,361,423 (+)NCBIGRCm37mm9NCBIm37
MGSCv36358,613,945 - 58,645,430 (+)NCBImm8
Celera358,218,434 - 58,250,295 (+)NCBICelera
Cytogenetic Map3DNCBI
cM Map328.58NCBI
Eif2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22142,761,303 - 142,794,767 (+)NCBI
Rnor_6.0 Ensembl2148,722,231 - 148,755,520 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02148,722,343 - 148,755,781 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02168,139,922 - 168,173,823 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42147,870,265 - 147,903,411 (+)NCBIRGSC3.4rn4RGSC3.4
Celera2137,190,037 - 137,223,189 (+)NCBICelera
Cytogenetic Map2q26NCBI
Eif2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554481,743,060 - 1,781,466 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554481,743,060 - 1,781,401 (+)NCBIChiLan1.0ChiLan1.0
EIF2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13155,137,789 - 155,175,492 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3155,137,410 - 155,175,492 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03147,564,293 - 147,601,939 (+)NCBIMhudiblu_PPA_v0panPan3
EIF2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2345,202,022 - 45,235,559 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12345,202,663 - 45,235,559 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Eif2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936758960,305 - 992,152 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1390,761,465 - 90,804,276 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11390,761,453 - 90,804,274 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21398,845,780 - 98,862,631 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EIF2A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11540,112,926 - 40,146,629 (-)NCBI
ChlSab1.1 Ensembl1540,111,878 - 40,146,554 (-)Ensembl
Eif2a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473027,973,622 - 28,013,434 (+)NCBI

Position Markers
A009D27  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373150,282,465 - 150,282,566UniSTSGRCh37
Build 363151,765,155 - 151,765,256RGDNCBI36
Celera3148,695,499 - 148,695,600RGD
Cytogenetic Map3q25.1UniSTS
HuRef3147,656,149 - 147,656,250UniSTS
GeneMap99-GB4 RH Map3550.43UniSTS
NCBI RH Map31319.3UniSTS
WI-11937  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373150,301,883 - 150,301,989UniSTSGRCh37
Build 363151,784,573 - 151,784,679RGDNCBI36
Celera3148,714,922 - 148,715,028RGD
Cytogenetic Map3q25.1UniSTS
HuRef3147,675,569 - 147,675,675UniSTS
GeneMap99-GB4 RH Map3548.21UniSTS
Whitehead-RH Map3680.9UniSTS
NCBI RH Map31321.6UniSTS
SHGC-77450  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373150,301,823 - 150,301,927UniSTSGRCh37
Build 363151,784,513 - 151,784,617RGDNCBI36
Celera3148,714,862 - 148,714,966RGD
Cytogenetic Map3q25.1UniSTS
HuRef3147,675,509 - 147,675,613UniSTS
TNG Radiation Hybrid Map384750.0UniSTS
GeneMap99-GB4 RH Map3548.21UniSTS
NCBI RH Map31321.6UniSTS
STS-N73885  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373150,302,694 - 150,302,873UniSTSGRCh37
Build 363151,785,384 - 151,785,563RGDNCBI36
Celera3148,715,733 - 148,715,912RGD
Cytogenetic Map3q25.1UniSTS
HuRef3147,676,380 - 147,676,559UniSTS
GeneMap99-GB4 RH Map3548.31UniSTS
NCBI RH Map31321.6UniSTS
RH48541  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373150,263,313 - 150,263,453UniSTSGRCh37
Build 363151,746,003 - 151,746,143RGDNCBI36
Celera3148,676,216 - 148,676,356RGD
Cytogenetic Map3q25.1UniSTS
HuRef3147,637,019 - 147,637,159UniSTS
GeneMap99-GB4 RH Map3548.31UniSTS
NCBI RH Map31321.6UniSTS
WI-14136  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373150,303,638 - 150,303,787UniSTSGRCh37
Build 363151,786,328 - 151,786,477RGDNCBI36
Celera3148,716,673 - 148,716,822RGD
Cytogenetic Map3q25.1UniSTS
HuRef3147,677,320 - 147,677,469UniSTS
GeneMap99-GB4 RH Map3561.18UniSTS
Whitehead-RH Map3672.5UniSTS
STS-T69826  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373150,282,489 - 150,282,671UniSTSGRCh37
Build 363151,765,179 - 151,765,361RGDNCBI36
Celera3148,695,523 - 148,695,705RGD
Cytogenetic Map3q25.1UniSTS
HuRef3147,656,173 - 147,656,355UniSTS
GeneMap99-GB4 RH Map3548.31UniSTS
NCBI RH Map31321.6UniSTS
EIF2a_2918  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373150,301,610 - 150,302,172UniSTSGRCh37
Build 363151,784,300 - 151,784,862RGDNCBI36
Celera3148,714,649 - 148,715,211RGD
HuRef3147,675,296 - 147,675,858UniSTS
G32449  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373150,282,465 - 150,282,566UniSTSGRCh37
Celera3148,695,499 - 148,695,600UniSTS
Cytogenetic Map3q25.1UniSTS
HuRef3147,656,149 - 147,656,250UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1846
Count of miRNA genes:727
Interacting mature miRNAs:810
Transcripts:ENST00000273435, ENST00000383043, ENST00000406576, ENST00000460851, ENST00000462221, ENST00000463863, ENST00000465535, ENST00000469331, ENST00000472926, ENST00000473499, ENST00000474505, ENST00000477551, ENST00000482093, ENST00000482471, ENST00000487799, ENST00000490505, ENST00000494558
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2439 2793 1713 613 1826 454 4356 2124 3449 416 1459 1611 175 1 1203 2788 6 2
Low 198 13 11 125 11 1 73 285 3 1 2 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001319043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001319044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001319045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001319046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_032025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011513224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024453787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC107426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF109358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF172818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF212241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF497978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI560242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK027356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL833101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA382303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000273435   ⟹   ENSP00000273435
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3150,546,794 - 150,584,242 (+)Ensembl
RefSeq Acc Id: ENST00000406576   ⟹   ENSP00000385292
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3150,546,787 - 150,584,115 (+)Ensembl
RefSeq Acc Id: ENST00000460851   ⟹   ENSP00000417229
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3150,546,787 - 150,586,016 (+)Ensembl
RefSeq Acc Id: ENST00000462221   ⟹   ENSP00000420495
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3150,546,814 - 150,572,061 (+)Ensembl
RefSeq Acc Id: ENST00000463863
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3150,546,678 - 150,558,729 (+)Ensembl
RefSeq Acc Id: ENST00000465535   ⟹   ENSP00000420611
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3150,568,032 - 150,584,234 (+)Ensembl
RefSeq Acc Id: ENST00000469331
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3150,546,790 - 150,562,908 (+)Ensembl
RefSeq Acc Id: ENST00000472926
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3150,567,399 - 150,568,219 (+)Ensembl
RefSeq Acc Id: ENST00000473499
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3150,546,725 - 150,552,883 (+)Ensembl
RefSeq Acc Id: ENST00000474505
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3150,546,786 - 150,564,899 (+)Ensembl
RefSeq Acc Id: ENST00000477551   ⟹   ENSP00000420493
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3150,552,354 - 150,584,242 (+)Ensembl
RefSeq Acc Id: ENST00000482093   ⟹   ENSP00000418698
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3150,546,788 - 150,568,026 (+)Ensembl
RefSeq Acc Id: ENST00000482471
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3150,572,496 - 150,583,903 (+)Ensembl
RefSeq Acc Id: ENST00000487799   ⟹   ENSP00000420537
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3150,546,685 - 150,584,023 (+)Ensembl
RefSeq Acc Id: ENST00000490505   ⟹   ENSP00000417575
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3150,546,800 - 150,564,377 (+)Ensembl
RefSeq Acc Id: ENST00000494558   ⟹   ENSP00000419456
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3150,546,767 - 150,568,274 (+)Ensembl
RefSeq Acc Id: NM_001319043   ⟹   NP_001305972
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383150,546,787 - 150,586,016 (+)NCBI
CHM1_13150,227,518 - 150,266,862 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001319044   ⟹   NP_001305973
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383150,546,787 - 150,586,016 (+)NCBI
CHM1_13150,227,518 - 150,266,862 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001319045   ⟹   NP_001305974
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383150,546,787 - 150,586,016 (+)NCBI
CHM1_13150,227,518 - 150,266,862 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001319046   ⟹   NP_001305975
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383150,546,787 - 150,586,016 (+)NCBI
CHM1_13150,227,518 - 150,266,862 (+)NCBI
Sequence:
RefSeq Acc Id: NM_032025   ⟹   NP_114414
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383150,546,787 - 150,586,016 (+)NCBI
GRCh373150,264,465 - 150,303,803 (+)NCBI
Build 363151,747,264 - 151,786,493 (+)NCBI Archive
HuRef3147,638,280 - 147,677,485 (+)ENTREZGENE
CHM1_13150,227,518 - 150,266,862 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011513224   ⟹   XP_011511526
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383150,546,726 - 150,584,242 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024453787   ⟹   XP_024309555
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383150,546,800 - 150,584,242 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_114414   ⟸   NM_032025
- Peptide Label: isoform 1
- UniProtKB: Q9BY44 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011511526   ⟸   XM_011513224
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001305975   ⟸   NM_001319046
- Peptide Label: isoform 5
- UniProtKB: Q9BY44 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001305973   ⟸   NM_001319044
- Peptide Label: isoform 3
- UniProtKB: Q9BY44 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001305974   ⟸   NM_001319045
- Peptide Label: isoform 4
- UniProtKB: Q9BY44 (UniProtKB/Swiss-Prot),   F8WAE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001305972   ⟸   NM_001319043
- Peptide Label: isoform 2
- UniProtKB: Q9BY44 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_024309555   ⟸   XM_024453787
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSP00000420493   ⟸   ENST00000477551
RefSeq Acc Id: ENSP00000420611   ⟸   ENST00000465535
RefSeq Acc Id: ENSP00000417575   ⟸   ENST00000490505
RefSeq Acc Id: ENSP00000419456   ⟸   ENST00000494558
RefSeq Acc Id: ENSP00000418698   ⟸   ENST00000482093
RefSeq Acc Id: ENSP00000273435   ⟸   ENST00000273435
RefSeq Acc Id: ENSP00000385292   ⟸   ENST00000406576
RefSeq Acc Id: ENSP00000420537   ⟸   ENST00000487799
RefSeq Acc Id: ENSP00000417229   ⟸   ENST00000460851
RefSeq Acc Id: ENSP00000420495   ⟸   ENST00000462221
Protein Domains
eIF2A

Promoters
RGD ID:6865988
Promoter ID:EPDNEW_H6159
Type:initiation region
Name:EIF2A_1
Description:eukaryotic translation initiation factor 2A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh383150,546,787 - 150,546,847EPDNEW
RGD ID:6800880
Promoter ID:HG_KWN:46466
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_2Hour
Transcripts:ENST00000406576,   NM_032025,   UC003EYB.1,   UC003EYC.1
Position:
Human AssemblyChrPosition (strand)Source
Build 363151,746,136 - 151,746,636 (+)MPROMDB
RGD ID:6800932
Promoter ID:HG_KWN:46468
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:ENST00000383043
Position:
Human AssemblyChrPosition (strand)Source
Build 363151,767,161 - 151,767,661 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3q24-26.32(chr3:147442566-178522531)x3 copy number gain See cases [RCV000051724] Chr3:147442566..178522531 [GRCh38]
Chr3:147160353..178240319 [GRCh37]
Chr3:148643043..179723013 [NCBI36]
Chr3:3q24-26.32
pathogenic
GRCh38/hg38 3q24-29(chr3:147521892-198096565)x3 copy number gain See cases [RCV000051725] Chr3:147521892..198096565 [GRCh38]
Chr3:147239679..197823436 [GRCh37]
Chr3:148722369..199307833 [NCBI36]
Chr3:3q24-29
pathogenic
GRCh38/hg38 3q22.3-29(chr3:137126982-198110178)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051723]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051723]|See cases [RCV000051723] Chr3:137126982..198110178 [GRCh38]
Chr3:136845824..197837049 [GRCh37]
Chr3:138328514..199321446 [NCBI36]
Chr3:3q22.3-29
pathogenic
GRCh38/hg38 3q25.1(chr3:150462960-150915627)x1 copy number loss See cases [RCV000053994] Chr3:150462960..150915627 [GRCh38]
Chr3:150180747..150633414 [GRCh37]
Chr3:151663437..152116104 [NCBI36]
Chr3:3q25.1
uncertain significance
GRCh38/hg38 3q13.11-29(chr3:103426882-198110178)x3 copy number gain See cases [RCV000134948] Chr3:103426882..198110178 [GRCh38]
Chr3:103145726..197837049 [GRCh37]
Chr3:104628416..199321446 [NCBI36]
Chr3:3q13.11-29
pathogenic
GRCh37/hg19 3q24-29(chr3:142995020-192997215)x4 copy number gain See cases [RCV000240256] Chr3:142995020..192997215 [GRCh37]
Chr3:3q24-29
pathogenic
GRCh37/hg19 3q24-25.2(chr3:148425748-153220169)x1 copy number loss See cases [RCV000447056] Chr3:148425748..153220169 [GRCh37]
Chr3:3q24-25.2
pathogenic
GRCh37/hg19 3q24-26.2(chr3:147180945-168415875)x1 copy number loss See cases [RCV000448130] Chr3:147180945..168415875 [GRCh37]
Chr3:3q24-26.2
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3q24-25.1(chr3:144053029-150272658)x1 copy number loss not provided [RCV001005476] Chr3:144053029..150272658 [GRCh37]
Chr3:3q24-25.1
likely pathogenic
GRCh37/hg19 3q22.3-26.1(chr3:138145289-162275610)x3 copy number gain See cases [RCV001194586] Chr3:138145289..162275610 [GRCh37]
Chr3:3q22.3-26.1
pathogenic
GRCh37/hg19 3q25.1-25.2(chr3:149404255-152786331)x1 copy number loss not provided [RCV001005477] Chr3:149404255..152786331 [GRCh37]
Chr3:3q25.1-25.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3254 AgrOrtholog
COSMIC EIF2A COSMIC
Ensembl Genes ENSG00000144895 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000273435 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000385292 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000417229 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000417575 UniProtKB/TrEMBL
  ENSP00000418698 UniProtKB/TrEMBL
  ENSP00000419456 UniProtKB/TrEMBL
  ENSP00000420493 UniProtKB/TrEMBL
  ENSP00000420495 UniProtKB/TrEMBL
  ENSP00000420537 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000420611 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENST00000273435 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000406576 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000460851 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000462221 UniProtKB/TrEMBL
  ENST00000465535 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000477551 UniProtKB/TrEMBL
  ENST00000482093 UniProtKB/TrEMBL
  ENST00000487799 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000490505 UniProtKB/TrEMBL
  ENST00000494558 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000144895 GTEx
HGNC ID HGNC:3254 ENTREZGENE
Human Proteome Map EIF2A Human Proteome Map
InterPro TIF2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIF_beta_prop-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot
KEGG Report hsa:83939 UniProtKB/Swiss-Prot
NCBI Gene 83939 ENTREZGENE
OMIM 609234 OMIM
PANTHER PTHR13227 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam eIF2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA143485453 PharmGKB
PIRSF eIF2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot
UniProt C9IZE1_HUMAN UniProtKB/TrEMBL
  EIF2A_HUMAN UniProtKB/Swiss-Prot
  F8WAE5 ENTREZGENE, UniProtKB/TrEMBL
  F8WAT3_HUMAN UniProtKB/TrEMBL
  F8WF18_HUMAN UniProtKB/TrEMBL
  H7C5Q3_HUMAN UniProtKB/TrEMBL
  H7C5Q4_HUMAN UniProtKB/TrEMBL
  H7C5R5_HUMAN UniProtKB/TrEMBL
  Q9BY44 ENTREZGENE
UniProt Secondary A8MPS6 UniProtKB/Swiss-Prot
  B4DF96 UniProtKB/Swiss-Prot
  B4DQ14 UniProtKB/Swiss-Prot
  D3DNI9 UniProtKB/Swiss-Prot
  Q5QTR2 UniProtKB/Swiss-Prot
  Q7Z4E9 UniProtKB/Swiss-Prot
  Q8NFM1 UniProtKB/Swiss-Prot
  Q96EW9 UniProtKB/Swiss-Prot
  Q96K81 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-05 EIF2A  eukaryotic translation initiation factor 2A    eukaryotic translation initiation factor 2A, 65kDa  Symbol and/or name change 5135510 APPROVED
2011-08-16 EIF2A  eukaryotic translation initiation factor 2A, 65kDa  EIF2A  eukaryotic translation initiation factor 2A, 65kDa  Symbol and/or name change 5135510 APPROVED