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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1589363
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstz1
Name: glutathione S-transferase zeta 1
Acc ID: CHEBI:36386
Term: dichloroacetic acid
Definition: An organochlorine compound comprising acetic acid carrying two chloro substituents at the 2-position. It occurs in nature in seaweed, Asparagopsis taxiformis.
Chemical ID: MESH:D003999
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstz1affects metabolic processingEXP 6480464CTDGSTZ1 protein affects the metabolism of Dichloroacetic AcidPMID:12019185 PMID:12441371 PMID:14599561
Gstz1decreases activityEXP 6480464CTDDichloroacetic Acid results in decreased activity of GSTZ1 proteinPMID:10471397 PMID:12441371 PMID:12730618 PMID:15625187
Gstz1decreases expressionEXP 6480464CTDDichloroacetic Acid results in decreased expression of GSTZ1 proteinPMID:14599561
Gstz1multiple interactionsEXP 6480464CTDDichloroacetic Acid results in decreased expression of and results in decreased activity of GSTZ1 protein; GSTZ1 protein affects the metabolism of and results in increased activity of Dichloroacetic AcidPMID:12019185 PMID:15144222 PMID:31524376
Gstz1affects metabolic processingISOGstz1 (Mus musculus)6480464CTDGSTZ1 protein affects the metabolism of Dichloroacetic AcidPMID:15277241
Gstz1decreases activityISOGSTZ1 (Homo sapiens)6480464CTDDichloroacetic Acid results in decreased activity of GSTZ1 protein; Dichloroacetic Acid results in decreased activity of GSTZ1 protein polymorphismPMID:12119007 PMID:12437329 PMID:24632415
Gstz1decreases activityISOGstz1 (Mus musculus)6480464CTDDichloroacetic Acid results in decreased activity of GSTZ1 proteinPMID:11960676
Gstz1increases metabolic processingISOGSTZ1 (Homo sapiens)6480464CTDGSTZ1 protein SNP results in increased metabolism of Dichloroacetic AcidPMID:10739172
Gstz1increases metabolic processingISOGstz1 (Mus musculus)6480464CTDGSTZ1 protein results in increased metabolism of Dichloroacetic AcidPMID:20045428
Gstz1multiple interactionsISOGSTZ1 (Homo sapiens)6480464CTDBromides inhibits the reaction [Dichloroacetic Acid results in decreased activity of GSTZ1 protein]; Chlorides inhibits the reaction [Dichloroacetic Acid results in decreased activity of GSTZ1 protein]; GSTZ1 protein binds to and affects the metabolism of Dichloroacetic Acid; Iodides inhibits the reaction [Dichloroacetic Acid results in decreased activity of GSTZ1 protein]; Sulfites inhibits the reaction [Dichloroacetic Acid results in decreased activity of GSTZ1 protein]PMID:12437329 PMID:24632415
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