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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1588455
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Thbs1
Name: thrombospondin 1
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Thbs1increases expressionEXP 6480464CTDStreptozocin results in increased expression of THBS1 mRNA; Streptozocin results in increased expression of THBS1 proteinPMID:17063547 PMID:17117553
Thbs1multiple interactionsEXP 6480464CTDpioglitazone inhibits the reaction [Streptozocin results in increased expression of THBS1 mRNA]; pioglitazone inhibits the reaction [Streptozocin results in increased expression of THBS1 protein]PMID:17063547
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